Comparison of Liver Enzymes and Hormonal Profiles Between Cholecystectomized Patients and Non-Cholecystectomized Controls

Abstract

Cholecystectomy is performed surgical procedure involving the removal of the gallbladder, that responsible for bile storage. The cholelithiasis, cholecystitis, and gallbladder cancer are gallbladder-related disorders that require cholecystectomy. The paper aims to compare liver enzymes levels and some gastrointestinal hormones between cholecystectomized Patients and controls. The study included 50 serum samples: 25 from Cholecystectomized patients and 25 from controls. The studied parameters include liver Enzymes (ALT, AST, ALP, and GGT). Also, the hormones (Cholecystokinin, Secretin, Gastrin, Insulin, Glucagon, and FGF19). The findings showed no significant differences between the patient and control groups for all liver enzymes at P≤0.05. Moreover, there are no significant differences in cholecystokinin, Secretin, Gastrin, Insulin, and Glucagon levels between the patient and the control. However, FGF19 decreased in the patient compared with the control. We can conclude that liver enzymes and some gastrointestinal hormones, except FGF19, don’t show significant differences between Cholecystectomized Patients and Controls.