A Non-Randomized clinical study to observe the efficacy of Individualized Homoeopathic medicine in the management of Melasma using Synthesis Repertory

Abstract

Background: Melasma is a recurrent, chronic hyperpigmentation disorder caused by hyperactive melanocytes leading to excessive melanin deposition in the epidermis and dermis. It commonly presents as marginated facial hyperpigmentation and significantly affects psychological well-being and quality of life. Research on its psychological burden and management in India remains limited. Homoeopathy, with its holistic and individualized approach, may provide therapeutic benefit where conventional treatments show limitations. Methods: A single-blind, prospective, non-randomized clinical study was conducted at the OPD of Bharati Vidyapeeth (Deemed to be University) Homoeopathic Medical College and Research Centre, Pune. Thirty patients aged ≥25 years were enrolled and completed follow-up. Individualized homoeopathic medicines were prescribed using the Synthesis Repertory. Outcomes were assessed using the Melasma Severity Index (MSI) and Melasma Quality of Life (MelasQoL) scales before and after intervention. Wilcoxon signed-rank test and paired t-test were applied. A p-value <0.05 was considered statistically significant. Results: Among 30 patients, 96.67% were female. Significant reduction was observed in MSI scores (Z = −4.787, p < 0.05), with median values decreasing from 10.80 to 4.64. MelasQoL scores reduced from 34.90 ± 6.48 to 15.77 ± 4.21, demonstrating statistically significant improvement (t (29) = 20.53, p < 0.05). Sulphur (30%), Lycopodium (20%), and Sepia (16.67%) were the most frequently prescribed remedies. Conclusion: Individualized homoeopathic treatment using the Synthesis Repertory showed statistically significant improvement in both disease severity and quality of life in patients with melasma. Larger controlled studies are recommended to validate these findings.