Preparation and evaluation of phospholipid complex to improve solubility of curcumin

Abstract

Water solubility, drug permeability, and metabolism are some of the elements that affect a medication's oral bioavailability. In medication development, poor solubility is a problem that frequently calls for particle size reduction methods like nanosization, which improves bioavailability. Important model terms and the significance of model reduction are revealed by statistical analysis. Additionally, thermal examination revealed a melting peak at 204.3°C and confirmed the successful synthesis of Cur-phospholipid complex with an average particle size of 170.2 nm, demonstrating curcumin's excipient compatibility. In comparison to traditional solutions, the improved formulation showed delayed drug release and a drug encapsulation effectiveness of 93.98%. Higher concentrations of the formulations reduced cell survival, according to studies on cell viability.