Study Effects of Actaea racemosa on Neurotoxicity in White Male Rats Exposed to Hyperhomocysteinemia

Abstract

Introduction: Homocysteine (Hcy) plays a critical function in the metabolism of methionine. Individuals who are affected by genetic variants of hyperhomocysteinemia face early vascular damage and cognitive impairment. Hyperhomocysteinemia is a complex disorder, emerging from a mix of dietary, behavioral, and pathogenic aspects. Aim: evaluted the possible role of Actaea Racemosa as neuroprotective against varied degrative marketers. Method: Thirty male albino rats were separated into 5 groups, 6 rats each, Sham animal which not got anything. Vehicle which got 1% starch gel solution, Control which administration of D-L-thioacetaldehyde homocysteine hydrochloride, Treatment animals which administered Actaea racemosa , and finaly Combination group: The animals were exposed to the same regimen as the control group, in addition to being injected 100 mg/kg of Actaea racemosa extract intragastrical once daily for eight weeks.  Results: Compared to the control group, our data revealed that Actaea racemosa significantly (p<0.05) elevated the levels of acetylcholine esterase (AchE, U/ml), dopamine (pg/ml), glutamate (mM/ml), SOD (ng/ml), and CAT (U/mg) in both the AR and combination groups. Simultaneously, Actaea racemosa therapy led to a marked reduction in neurofilament light (NfL, pg/ml), TNF-α (ng/ml), IL-1β (ng/ml), MDA (ng/ml), Hz (µMOL/L), β-amyloid (pg/ml), and t-tau (pg/ml). Conclusion: Neuroprotective effects of Actaea Racemosa in mitigating cerebral injury through the upregulation of neuro-hormones and antioxidant proteins, alongside the downregulation of pro inflammatory markers and neurodegenerative proteins.