Study of Antimalarial Activity of Dalbergia sissoo Roxb. ex DC. Through β Hematin Inhibition Assay

Abstract

Background: Globally Malaria known as major infectious disease, which causes significant illness and death, particularly in tropical and subtropical regions. As a result of the increasing resistance to traditional antimalarial drugs, there is a need to find new antimalarial drugs from natural sources, such as Dalbergia sissoo Roxb., which has been traditionally used to treat Snake bite, fever, infections, and inflammation. Material and Methods: This study examines the antimalarial potential of Dalbergia sissoo leaf extract by assessing its capacity to inhibit beta-hematin formation, a critical process in the detoxification pathway of Plasmodium falciparum parasites. The research tis done in-vitro antimalarial testing using UV spectroscopy and FTIR methods. Results: Due to the presence of phenolic compounds, flavonoids, tannins, and other bioactive substances suggests potential antiplasmodial activity. Since flavonoids and phenolics are known to interfere with hemozoin formation, Dalbergia sissoo may be a valuable source of antimalarial compounds. Conclusion: The findings of this study could support the development of effective antimalarial treatments derived from plants.