Environmental Pollution and Cytotoxic Effects of Metallic Nanoparticles: Integrating Mechanistic Toxicology with Support Vector Regression-Based Predictive Modeling

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Published: 2026-05-12
DOI: https://doi.org/10.70102/IJARES/V6S1/6-S1-495
Keywords:
Metallic nanoparticles, Environmental pollution, Cytotoxicity, Oxidative stress, Nanotoxicology, Cell viability

Main Article Content

Dhirendra Singh
Assistant professor, Department of Biotechnology Engineering, Khwaja Moinuddin Chishti Language University, Lucknow, Uttar Pradesh
Shivanshi Tripathi
Assistant professor, Department of Biotechnology Engineering, Khwaja Moinuddin Chishti Language University, Lucknow, Uttar Pradesh
Ratnesh Kumar Singh
Assistant professor, Department of Zoology, Khwaja Moinuddin Chishti Language University, Lucknow, Uttar Pradesh
Apeksha Singh
Assistant professor, Faculty of Pharmacy, Khwaja Moinuddin Chishti Language University, Lucknow, Uttar Pradesh

Abstract

The prevalent application of metallic nanoparticles (NPs) in various industries, biomedical sector, agricultural field, and products for consumers leads growing concerns regarding their environmental release and potential toxicological effects. Nanoparticles such as silver (Ag) NPs, zinc oxide (ZnO) NPs, Titanium Dioxide (TiO₂) NPs, copper (Cu) NPs, & gold (Au) NPs possess unique physicochemical properties that enhance their functionality but also increase their environmental mobility and biological reactivity. Upon entering aquatic and terrestrial ecosystems, these nanoparticles can accumulate and interact with living organisms, potentially disrupting ecological balance. Numerous studies have demonstrated that metallic nanoparticles induce cytotoxic effects through mechanisms including oxidative stress, membrane damage, mitochondrial dysfunction, inflammation, and DNA damage. In - vitro live cell-based assays have been extensively used to measure nanoparticle-induced toxicity. Understanding the environmental fate and cytotoxic mechanisms of metallic nanoparticles is crucial for developing safer nanomaterials and establishing effective regulatory strategies for environmental protection and public health.

Article Details

Issue

Vol. 6 No. S1 (2026): Volume 6, Issue S1, 2026

Section

Articles

How to Cite

Environmental Pollution and Cytotoxic Effects of Metallic Nanoparticles: Integrating Mechanistic Toxicology with Support Vector Regression-Based Predictive Modeling (D. Singh, S. Tripathi, R. Kumar Singh, & A. Singh, Trans.). (2026). International Journal of Aquatic Research and Environmental Studies, 6(S1), 726-743. https://doi.org/10.70102/IJARES/V6S1/6-S1-495

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