Synthesis Characterization and Study the Antibacterial Activity of Some Transition Metal Complexes of New Thiosemicarbazide Ligand
Main Article Content
Abstract
N-(2-carbamothioylhydrazine-1-carbonothioyl)-4-methoxybenzamide (L), a new thiosimecarbazide ligand, was prepared and characterised as part of the study. Three coordination were separated from the combination of the title ligand and the metal ions cobalt (II), nickel (II), and copper (II). Using EtOH as the medium, a 1:1 mole ratio of metal to ligand was used to carry out the reaction. The isolated coordination compounds have the following general chemical formula; [LMCl2.H2O)] M(II)= (Co, Ni and Cu). The structural identity of the predicted ligand and its metal complexes have been exhaustively established using various analytical and physico-chemical approaches. These consist of melting point, electronic spectra, FTIR Spectroscopy, and also (1H and 13C) Nuclear Magnetic Resonance spectra. Based on the analytical and spectroscopic data collected, it was found that the synthesized complexes (Co), (Ni) and (Cu) adopted a six-coordinate configuration with a characteristic distorted octahedral environment around the metal center. G+ and G- species antibacterial activity was investigated.
Article Details
Section
How to Cite
References
References
1. Mosa, A., et al., Novel transition metal complexes of 4-hydroxy-coumarin-3-thiocarbohydrazone: Pharmacodynamic of Co (III) on rats and antimicrobial activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2011. 81(1): p. 35-43.
2. Farrell, N., Biomedical uses and applications of inorganic chemistry. An overview. Coordination Chemistry Reviews, 2002. 232(1-2): p. 1-4.
3. Dragancea, D., et al., Trinuclear cyanido-bridged MII-WV complexes (M= Mn, Co): Crystal structures and magnetic properties. Polyhedron, 2022. 220: p. 115839.
4. Dawoud, S.M. Synthesis and DNA binding study of Co (II) and V (IV) complexes with O, N, O tridentate 3-methoxysalicylaldehyde-semicarbazide based ligand. in Journal of Physics: Conference Series. 2021. IOP Publishing.
5. Dilworth, J.R. and R. Hueting, Metal complexes of thiosemicarbazones for imaging and therapy. Inorganica Chimica Acta, 2012. 389: p. 3-15.
6. Lobana, T.S., et al., Bonding and structure trends of thiosemicarbazone derivatives of metals—an overview. Coordination Chemistry Reviews, 2009. 253(7-8): p. 977-1055.
7. Belikov, M.Y. and A.G. Milovidova, Synthesis of heterocyclic compounds containing the 3, 3-dicyanoacrylamide fragment. Chemistry of Heterocyclic Compounds, 2021. 57: p. 1-6.
8. Salah, N., et al., Novel NO2 semicarbazone ligand and its metal complexes as VEGFR‐2 inhibitors: Synthesis, spectral characterization, density functional theory calculations, molecular docking, and antimicrobial and antitumor evaluation. Applied Organometallic Chemistry, 2022. 36(10): p. e6845.
9. Kavitha, P. and K.L. Reddy, Pd (II) complexes bearing chromone based Schiff bases: Synthesis, characterisation and biological activity studies. Arabian Journal of Chemistry, 2016. 9(5): p. 640-648.
10. Ammar, R.A., et al., Synthesis, spectroscopic, molecular structure, antioxidant, antimicrobial and antitumor
behavior of Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) complexes of O2N type tridentate chromone-2-carboxaldehyde Schiff's base ligand. Journal of Molecular Structure, 2017. 1141: p. 368-381.
11. Dawood, Z., S. Hussein, and M. Al-Shama’a, SOME COMPLEXES OF Ni (II) CONTAINING MIXES LIGANDS. Sciences & Technology. A, exactes sciences, 2004: p. 71-75.
12. Volkert, W.A. and T.J. Hoffman, Therapeutic radiopharmaceuticals. Chemical reviews, 1999. 99(9): p. 2269-2292.
13. Castonguay, L., et al., Prediction of q-values and conformations of gadolinium chelates for magnetic resonance imaging. Bioconjugate chemistry, 1999. 10(6): p. 958-964.
14. Bal, S. and S.S. Bal, Cobalt (II) and Manganese (II) complexes of novel Schiff bases, synthesis, charcterization and thermal, antimicrobial, electronic, and catalytic features. Adv. Chem, 2014. 2014: p. 1-12.
15. Hussien, N.J., Alshawi, J.M., and Abdullah,K.T., Dimethyltin (IV) complexes of new thiosemicarbazone ligand with piperazine1-yimethylene moiety: Synthesis, spectral characterization and antibacterial activity. Edelweiss Applied Science and Technology, 2025. 9(3), pp. 266–278
16. Hussain, S.A. and M.J. Al-Jeboori, New metal complexes derived from Mannich-base ligand; Synthesis, spectral characterisation and biological activity. J. Global Pharma Tech, 2019. 11(2): p. 548-560.
17. Mahmood, M.R., et al., Synthesis, Characterization and Biological Activity Study of a New Schiff Base-Oxime Derived Ligand and Its Complexes with Some Metal IonsProceedings of International Conference on Applied Innovation in IT., 2025. 13(2), pp. 667–677.
18. Abdullah, K.T., et al., SPECTROSCOPIC AND BIOLOGICAL STUDIES OF Pd(II) COMPLEXES OF 5-(p-TOLYL)-1,3,4-OXADIAzOLE-2-THIOLBulletin of the Chemical Society of Ethiopia., 2025. 39(1), pp. 79–90
19. González-García, C., et al., Synthesis and antimicrobial activity of tetradentate ligands bearing hydrazone and/or thiosemicarbazone motifs and their diorganotin (IV) complexes. Journal of inorganic biochemistry, 2016. 163: p. 118-130.
20. Hariri, E., et al., Synthesis and antibacterial activity of novel hydroxy semicarbazone derivatives. Iranian Journal of Pharmaceutical Research: IJPR, 2016. 15(Suppl): p. 29.
21. Singh, H., J. Singh, and K. Sharma, Synthetic, structural, and antimicrobial studies of organotin (IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde. Research on chemical intermediates, 2012. 38: p. 53-65.
22. Zayed, E.M., et al., Coordination behaviour and biological activity studies involving theoretical docking of bis‐Schiff base ligand and some of its transition metal complexes. Applied Organometallic Chemistry, 2018. 32(12): p. e4603.
23. Ilhan, S. and H. Temel, Synthesis and spectral studies of macrocyclic Cu (II), Ni (II) and Co (II) complexes by template reaction of 1, 4-bis (3-aminopropoxy) butane with metal (II) nitrate and salicylaldehyde derivatives. Journal of molecular structure, 2008. 891(1-3): p. 157-166.
24. Zayed, E.M., M. Zayed, and A.M. Hindy, Thermal and spectroscopic investigation of novel Schiff base, its metal complexes, and their biological activities. Journal of Thermal Analysis and Calorimetry, 2014. 116: p. 391-400.
25. Pavia, D., et al., Introduction the Spectroscopy. USA: Cengage Learning. 2013.
26. Hasan, H.A., E.I. Yousif, and M.J. Al-Jeboori, Metal-assisted assembly of dinuclear metal (II) dithiocarbamate Schiff-base macrocyclic complexes: Synthesis and biological studies. Global J. Inorg. Chem, 2012. 3(10): p. 1-7.
27. Hussein, S.A. and E.I. Yousif, METAL COMPLEXES OF SEMICARBAZONE LIGAND DERIVED FROM MANNICH-β-AMINOCARBONYL: SYNTHESIS, STRUCTURAL CHARACTERISATION, THERMAL PROPERTIES AND BIOLOGICAL ACTIVITY.
28. Al-Qazzaz, A.H. and M.J. Al-Jeboori, New metal complexes derived from mannich ligands: Synthesis, spectral investigation and biological activity. Biochem. Cell. Arch, 2020. 20: p. 4207-4216.
29. Chandra, S. and L.K. Gupta, EPR, mass, IR, electronic, and magnetic studies on copper (II) complexes of semicarbazones and thiosemicarbazones. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005. 61(1-2): p. 269-275.
30. Ramachandran, E., et al., Synthesis, characterization and cytotoxic activity of novel copper (II) complexes with aroylhydrazone derivatives of 2-Oxo-1, 2-dihydrobenzo [h] quinoline-3-carbaldehyde. Journal of Inorganic Biochemistry, 2018. 182: p. 18-28.
31. Dong, X.-Y., et al., Structurally characterized solvent-induced homotrinuclear cobalt (II) N2O2-donor bisoxime-type complexes. Crystals, 2018. 8(3): p. 139.
32. Mahross, M.H., et al., Synthesis, characterization and corrosion inhibition of N′-phenylbenzohydrazide derivative metal complexes: Experimental and quantum chemical studies. Zeitschrift für Physikalische Chemie, 2019. 233(7): p. 949-972.
33. Al-Jeboori, M.J., A.H. Al-Dujaili, and A.E. Al-Janabi, Coordination of carbonyl oxygen in the complexes of polymeric N-crotonyl-2-hydroxyphenylazomethine. Transition Metal Chemistry, 2009. 34: p. 109-113.
34. Al-Rubaye, B.K., et al., Crystal structure of (E)-4-benzylidene-6-phenyl-1, 2, 3, 4, 7, 8, 9, 10-octahydrophenanthridine. Acta Crystallographica Section E: Crystallographic Communications, 2017. 73(7): p. 1092-1096.
35. Nair, M.S., D. Arish, and J. Johnson, Synthesis, characterization and biological studies on some metal complexes with Schiff base ligand containing pyrazolone moiety. Journal of Saudi Chemical Society, 2016. 20: p. S591-S598.
36. Jana, M.S., et al., Octahedral Mn (II) complex with new NNO donor Schiff base ligand: Synthesis, structure, photoluminescent behavior and computational studies. Polyhedron, 2014. 81: p. 66-73.
37. Chandra, S. and A. Gautam, Spectroscopic and biological approach in the characterization of Cr (III), Mn (II) and Co (II) complexes with a novel hexaazamacrocyclic ligand derived from semicarbazide. Journal of the Serbian Chemical Society, 2009. 74(12): p. 1413-1422.
38. El-Sayed, B., et al., Synthesis and structural study of the ligand o-OH acetophenone azine and its Cu (II), Ni (II), Co (II) and Zn (II) complexes. Vibrational spectroscopy, 2002. 30(1): p. 93-100.
39. Ye, Y., et al., Efficient removal of Cr (III)-organic complexes from water using UV/Fe (III) system: negligible Cr (VI) accumulation and mechanism. Water research, 2017. 126: p. 172-178.
40. Chouhan, O.P. and G. Jacob, FTIR, UV-Vis, Magnetic, Mass Spectral and XRD studies of Ni (II) complex with Pioglitazone: An Oral Antidiabetic Drug. Oriental Journal of Chemistry, 2014. 30(4): p. 1501.