Evaluating the Effectiveness of Combined Drug Therapy in Treating Diabetes

Abstract

Diabetes mellitus is a chronic, progressive metabolic disorder that often requires aggressive management to prevent long-term microvascular and macrovascular complications. While monotherapy (typically Metformin) is the standard initial approach, it frequently fails to maintain glycemic targets over time due to the progressive decline of pancreatic beta-cell function. Drug combination therapy has emerged as a comprehensive treatment strategy to achieve synergistic metabolic effects and address multiple pathophysiological pathways simultaneously.