Effects of Nano-Fipronil on the Haematological and Biochemical Parameters of Male Rats

Abstract

Although considered a good alternative to organophosphate pesticides, reports indicate adverse effects of neonicotinoid insecticides on reproduction. The present work was designed to determine the chronic effects of orally administered treatment with 5, 10, and 20 mg/kg. b.w. of Nano-Fipronil on the biochemical blood profile in male rats for a duration of 45 days. Result: The exposure caused a significant decline in red blood cell (RBC) and haemoglobin (Hb) levels in all treated groups compared with the control group. while raising white blood cells (WBCs) and blood platelets (PLT) in all treated rats relative to the control rats. Furthermore, oxidative stress parameters show a highly significant (P≤0.05) increase in malondialdehyde (MDA) after 60 d of exposure and a decline in the reduced glutathione (GSH) and catalase activity (CAT). The levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) increased in treated groups, while the levels of high density lipoprotein (HDL) decreased in treated groups compared to the control group.